BioLiP

Structure of PDB 3vui Chain A

Receptor sequence

>3vuiA (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]

DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKK
LSRPFQNQTHAKRAYRELVLMKVVNHKNIIGLLNVFTPQKSLEEFQDVYI
VMELMDANLSQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN
IVVKSDATLKILDFGLARTAGTSTPYVVTRYYRAPEVILGMGYKENVDIW
SVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPSPEFMKKLQPTVRTY
VENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKR
ISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE
VMDLE

3D structure

PDB

3vui Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1

Chain

Resolution

2.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1)	D145 K147 N150 D163 T179
Enzyme Commision number	2.7.11.24: mitogen-activated protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	M121 R127 Y130 S161 D162 A163 W324 E329	M115 R121 Y124 S155 D156 A157 W315 E320
BS02	SO4	A	R189 R192	R180 R183
BS03	SO4	A	K153 S155	K147 S149
BS04	SO4	A	R69 R72 R150 R174	R63 R66 R144 R168
BS05	SO4	A	Q37 G38 S58 H66	Q31 G32 S52 H60

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004707	MAP kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:3vui, PDBe:3vui, PDBj:3vui
PDBsum	3vui
PubMed	23020677
UniProt	P45983\|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)