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BioLiP

Structure of PDB 3cly Chain A

Receptor sequence
>3clyA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
LPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVK
MLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA
SKGNLREYLRARREEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT
HQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNE
LYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL
3D structure
PDB3cly A crystallographic snapshot of tyrosine trans-phosphorylation in action
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1626 A1628 R1630 N1631 D1644
Catalytic site (residue number reindexed from 1) D145 A147 R149 N150 D163
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N1631 D1644 N150 D163
BS02 ACP A A1515 K1517 A1567 N1571 L1633 D1644 A48 K50 A100 N104 L152 D163
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3cly, PDBe:3cly, PDBj:3cly
PDBsum3cly
PubMed19060208
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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