BioLiP

Structure of PDB 2zse Chain A

Receptor sequence

>2zseA (length=307) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]

EPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVEEVYLP
LARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVGKST
TARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNR
RALMRFVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNV
LQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADPESHFH
HYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDADHSIN
RLRLRKL

3D structure

PDB

2zse Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.1.33: pantothenate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ACP	A	V99 A100 V101 G102 S104 T105 R108 H179 M242	V94 A95 V96 G97 S99 T100 R103 H174 M237
BS02	PAU	A	Y235 R238 F239 M242 I272	Y230 R233 F234 M237 I267
BS03	FLC	A	R122 H194	R117 H189

Gene Ontology

	Molecular Function
GO:0004594	pantothenate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

	Biological Process
GO:0015937	coenzyme A biosynthetic process
GO:0016310	phosphorylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:2zse, PDBe:2zse, PDBj:2zse
PDBsum	2zse
PubMed	19307712
UniProt	P9WPA7\|COAA_MYCTU Pantothenate kinase (Gene Name=coaA)