Structure of PDB 2zse Chain A

Receptor sequence
>2zseA (length=307) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
EPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVEEVYLP
LARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVGKST
TARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNR
RALMRFVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNV
LQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADPESHFH
HYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDADHSIN
RLRLRKL
3D structure
PDB2zse Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A V99 A100 V101 G102 S104 T105 R108 H179 M242 V94 A95 V96 G97 S99 T100 R103 H174 M237
BS02 PAU A Y235 R238 F239 M242 I272 Y230 R233 F234 M237 I267
BS03 FLC A R122 H194 R117 H189
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zse, PDBe:2zse, PDBj:2zse
PDBsum2zse
PubMed19307712
UniProtP9WPA7|COAA_MYCTU Pantothenate kinase (Gene Name=coaA)

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