Structure of PDB 2pkn Chain A

Receptor sequence
>2pknA (length=323) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVA
GNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTA
RFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPE
AMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWD
LLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQT
DPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDY
EAAASRLAGAYGEHAAAEIVAVL
3D structure
PDB2pkn High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.20: adenosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A T223 L224 G225 G228 V243 A284 L288 T223 L224 G225 G228 V243 A284 L288
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004001 adenosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0032567 dGTP binding
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0016310 phosphorylation
GO:0044209 AMP salvage
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pkn, PDBe:2pkn, PDBj:2pkn
PDBsum2pkn
PubMed17597075
UniProtP9WID5|ADOK_MYCTU Adenosine kinase (Gene Name=adoK)

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