Structure of PDB 2piu Chain A

Receptor sequence
>2piuA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2piu A surface on the androgen receptor that allosterically regulates coactivator binding.
ChainA
Resolution2.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L701 L704 N705 Q711 M745 M749 F764 T877 L31 L34 N35 Q41 M75 M79 F94 T207 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02 4HY A K720 M734 I737 M894 I898 K50 M64 I67 M224 I228 BindingDB: IC50=34800nM
BS03 4HY A F673 G724 Y834 E837 F3 G54 Y164 E167 BindingDB: IC50=34800nM
External links
PDB RCSB:2piu, PDBe:2piu, PDBj:2piu
PDBsum2piu
PubMed17911242
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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