Structure of PDB 2lty Chain A

Receptor sequence
>2ltyA (length=34) Species: 9606 (Homo sapiens) [Search protein sequence]
PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIG
3D structure
PDB2lty Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
2.3.2.36: RING-type E3 ubiquitin transferase (cysteine targeting).
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A R374 K378 R380 Y382 V384 N385 H386 R389 T391 W393 R10 K14 R16 Y18 V20 N21 H22 R25 T27 W29
External links
PDB RCSB:2lty, PDBe:2lty, PDBj:2lty
PDBsum2lty
PubMed22921829
UniProtQ96PU5|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (Gene Name=NEDD4L)

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