Structure of PDB 1wvm Chain A

Receptor sequence

>1wvmA (length=435) Species: 247492 (Pseudoalteromonas sp. AS-11)

AETTPWGQTFVGATVLSDSQAGNRTICIIDSGYDRSHNDLNANNVTGTNN
SGTGNWYQPGNNNAHGTHVAGTIAAIANNEGVVGVMPNQNANIHIVKVFN
EAGWGYSSSLVAAIDTCVNSGGANVVTMSLGGSGSTTTERNALNTHYNNG
VLLIAAAGNAGDSSYSYPASYDSVMSVAAVDSNLDHAAFSQYTDQVEISG
PGEAILSTVTVGEGRLADITIGGQSYFSNGVVPHNRLTPSGTSYAPAPIN
ASATGALAECTVNGTSFSCGNMANKICLVERVGNQGSSYPEINSTKACKT
AGAKGIIVYSNSALPGLQNPFLVDANSDITVPSVSVDRATGLALKAKLGQ
STTVSNQGNQDYEYYNGTSMATPHVSGVATLVWSYHPECSASQVRAALNA
TADDLSVAGRDNQTGYGMINAVAAKAYLDESCTGP

3D structure

• PDB: 1wvm Crystal Structure of Psychrophilic Subtilisin-like Serine Protease from Antarctic Psychrotroph Pseudoalteromonas sp. AS-11 at 0.16 nm resolution
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D30 H65 N159 S369
• Catalytic site (residue number reindexed from 1): D30 H65 N159 S369
• Enzyme Commision number: 3.4.21.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	H65 F99 W104 S129 L130 G131 G158 N159 S166 S369	H65 F99 W104 S129 L130 G131 G158 N159 S166 S369
BS02	CA	A	E2 D39 I76 N78 E80 V82	E2 D39 I76 N78 E80 V82
BS03	CA	A	D404 L405 V407 G409 D411	D404 L405 V407 G409 D411
BS04	MG	A	L405 D411 T414 G415 G417	L405 D411 T414 G415 G417
BS05	MG	A	A169 Y171 V174 Q195	A169 Y171 V174 Q195
BS06	MG	A	M175 S176 Q195 E197	M175 S176 Q195 E197

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1wvm, PDBe:1wvm, PDBj:1wvm
• PDBsum: 1wvm
• UniProt: Q65Z69