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BioLiP

Structure of PDB 1vso Chain A

Receptor sequence
>1vsoA (length=243) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVK
LVPDGKYGAQWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLG
ISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWA
FMSSSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLID
SKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG
3D structure
PDB1vso Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AT1 A E13 Y61 P88 L89 T90 R95 G140 S141 E190 Y216 E9 Y57 P79 L80 T81 R86 G131 S132 E178 Y204 MOAD: Ki=18980nM
PDBbind-CN: -logKd/Ki=4.72,Ki=18.98uM
BindingDB: Ki=2900nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1vso, PDBe:1vso, PDBj:1vso
PDBsum1vso
PubMed17581823
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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