Structure of PDB 1mwt Chain A

Receptor sequence
>1mwtA (length=635) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
DKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVK
DINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLD
WDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPK
NVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSD
FAKKFHLTTNETESRNYPLEKATSHLLGYVGPINSEELKQKEYKGYKDDA
VIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKDGKDIQL
TIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMS
NEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLDDKTSYK
IDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGS
KKFEKGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILI
NPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQ
QVVNKTHKEDIYRSYANLIGKSGTAELGRQIGWFISYDKDNPNMMMAINV
KDVQDKGMASYNAKISGKVYDELYENGNKKYDIDE
3D structure
PDB1mwt Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.129: Transferred entry: 2.4.99.28.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNM A S403 Y446 S462 N464 Q521 S598 T600 Q613 S377 Y420 S436 N438 Q495 S572 T574 Q580 PDBbind-CN: -logKd/Ki=1.88,Kd=13.3mM
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0016757 glycosyltransferase activity
GO:0071972 peptidoglycan L,D-transpeptidase activity
Biological Process
GO:0046677 response to antibiotic
GO:0071555 cell wall organization
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1mwt, PDBe:1mwt, PDBj:1mwt
PDBsum1mwt
PubMed12389036
UniProtQ93IC2

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