Structure of PDB 1lvm Chain A

Receptor sequence

>1lvmA (length=229) Species: 12227 (Tobacco etch virus) [Search protein sequence]

GHHHHHHHGESLFKGPRDYNPISSTICHLTNESDGHTTSLYGIGFGPFII
TNKHLFRRNNGTLLVQSLHGVFKVKNTTTLQQHLIDGRDMIIIRMPKDFP
PFPQKLKFREPQREERICLVTTNFQTKSMSSMVSDTSCTFPSSDGIFWKH
WIQTKDGQCGSPLVSTRDGFIVGIHSASNFTNTNNYFTSVPKNFMELLTN
QEAQQWVSGWRLNADSVLWGGHKVFMDKP

3D structure

PDB

1lvm Structural basis for the substrate specificity of tobacco etch virus protease.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.
3.4.-.-
3.4.22.44: nuclear-inclusion-a endopeptidase.
3.4.22.45: helper-component proteinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	H46 D81 T146 C151 H167 S168 A169 S170 N171 F172 N174 N176 Y178 H214 K215 V216 F217 M218 K220	H54 D89 T154 C159 H175 S176 A177 S178 N179 F180 N182 N184 Y186 H222 K223 V224 F225 M226 K228
BS02	peptide	A	V63 F64 K65 K67 D90	V71 F72 K73 K75 D98

Gene Ontology

	Molecular Function
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:1lvm, PDBe:1lvm, PDBj:1lvm
PDBsum	1lvm
PubMed	12377789
UniProt	P04517\|POLG_TEV Genome polyprotein

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