Structure of PDB 1jft Chain A

Receptor sequence
>1jftA (length=340) Species: 562 (Escherichia coli) [Search protein sequence]
ATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVA
RSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNL
EKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDAGEAK
ADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFM
KAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMA
MGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETA
FNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR
3D structure
PDB1jft Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S14 T16 T17 R26 V28 A29 T32 L54 K55 S13 T15 T16 R25 V27 A28 T31 L53 K54 PDBbind-CN: Kd=0.7nM
BS02 HPA A Y73 F74 R190 T192 R196 F221 D275 Y72 F73 R189 T191 R195 F220 D274
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001217 DNA-binding transcription repressor activity
GO:0002057 guanine binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:1900372 negative regulation of purine nucleotide biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jft, PDBe:1jft, PDBj:1jft
PDBsum1jft
PubMed11781089
UniProtP0ACP7|PURR_ECOLI HTH-type transcriptional repressor PurR (Gene Name=purR)

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