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BioLiP

Structure of PDB 1dmy Chain A

Receptor sequence
>1dmyA (length=237) Species: 10090 (Mus musculus) [Search protein sequence]
GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSC
EDSGISGGPLGNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELHLVHWN
STKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQV
AMGPFDPSCLMPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLS
MFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSFR
3D structure
PDB1dmy Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y64 H94 H96 E106 H119 T199
Catalytic site (residue number reindexed from 1) Y40 H70 H72 E82 H95 T175
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H94 H96 H119 H70 H72 H95
BS02 AZM A H94 H96 H119 Y131 L198 T199 T200 H70 H72 H95 Y107 L174 T175 T176 BindingDB: Ki=60nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:1dmy, PDBe:1dmy, PDBj:1dmy
PDBsum1dmy
PubMed7479916
UniProtP23589|CAH5A_MOUSE Carbonic anhydrase 5A, mitochondrial (Gene Name=Ca5a)

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