Structure of PDB 1d9i Chain A

Receptor sequence
>1d9iA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
ADCGLRPLFEKKSLEDKTERELLESYIDIVEGSDAEIGMSPWQVMLFRKS
PQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYE
RNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPD
RETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRI
RITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGE
GCDRDGKYGFYTHVFRLKKWIQKVIDQFG
3D structure
PDB1d9i Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H71 D127 E223 G224 D225 S226 G227
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F34 K36 Q38 L65 R67 R73 T74 R75 Y76 K81 I82 F47 K49 Q52 L88 R90 R96 T97 R98 Y99 K105 I106
BS02 00P A H57 Y60A W60D I174 C191 E192 S214 W215 G216 E217 G219 H71 Y75 W78 I200 C222 E223 S247 W248 G249 E250 G251 MOAD: Ki=0.78nM
PDBbind-CN: -logKd/Ki=9.11,Ki=0.78nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1d9i, PDBe:1d9i, PDBj:1d9i
PDBsum1d9i
PubMed10713516
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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