BioLiP

Structure of PDB 1czm Chain A

Receptor sequence

>1czmA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]

ASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVS
YNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGST
NEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKV
GEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTH
PPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQP
LKGRTVRASF

3D structure

PDB

1czm Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme.

Chain

Resolution

2.0 Å

3D
structure

Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Catalytic site (original residue number in PDB)	H64 H94 H96 E106 H119 T199
Catalytic site (residue number reindexed from 1)	H64 H94 H96 E106 H119 T199
Enzyme Commision number	4.2.1.1: carbonic anhydrase. 4.2.1.69: cyanamide hydratase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H94 H96 H119	H94 H96 H119
BS02	AAS	A	H94 H119 L198 T199 H200	H94 H119 L198 T199 H200

Gene Ontology

	Molecular Function
GO:0004064	arylesterase activity
GO:0004089	carbonate dehydratase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016829	lyase activity
GO:0016836	hydro-lyase activity
GO:0018820	cyanamide hydratase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006730	one-carbon metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

PDB	RCSB:1czm, PDBe:1czm, PDBj:1czm
PDBsum	1czm
PubMed	7932756
UniProt	P00915\|CAH1_HUMAN Carbonic anhydrase 1 (Gene Name=CA1)