Structure of PDB 1a0d Chain A

Receptor sequence

>1a0dA (length=437) Species: 1422 (Geobacillus stearothermophilus)

PYFDNISTIAYEGPASKNPLAFKFYNPEEKVGDKTMEEHLRFSVAYWHTF
TGDGSDPFGAGNMIRPWNKYSGMDLAKARVEAAFEFFEKLNIPFFCFHDV
DIAPEGETLKETYKNLDIIVDMIEEYMKTSKTKLLWNTANLFTHPRFVHG
AATSCNADVFAYAAAKVKKGLEIAKRLGAENYVFWGGREGYETLLNTDMK
LELDNLARFLHMAVDYAKEIGFDGQFLIEPKPKEPTKHQYDFDVATALAF
LQTYGLKDYFKFNIEANHATLAGHTFEHELRVARIHGMLGSVDANQGDML
LGWDTDEFPTDLYSTTLAMYEILKNGGLGRGGLNFDAKVRRGSFEPEDLF
YAHIAGMDSFAVGLKVAHRLIEDRVFDEFIEERYKSYTEGIGREIVEGTA
DFHKLEAHALQLGEIQNQSGRQERLKTLLNQYLLEVC

3D structure

• PDB: 1a0d High Level Expression of a Thermostable Bacillus Xylose (Glucose) Isomerase in Escherichia Coli
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H98 D101 W136 E229 K231 E265 H268 D293 D304 D306 D336
• Catalytic site (residue number reindexed from 1): H98 D101 W136 E229 K231 E265 H268 D293 D304 D306 D336
• Enzyme Commision number: 5.3.1.5: xylose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	E229 E265 D293 D336	E229 E265 D293 D336
BS02	MN	A	E265 H268 D304 D306	E265 H268 D304 D306

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0009045 xylose isomerase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0042732 D-xylose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1a0d, PDBe:1a0d, PDBj:1a0d
• PDBsum: 1a0d
• UniProt: P54273|XYLA_GEOSE Xylose isomerase (Gene Name=xylA)