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BioLiP

Structure of PDB 4ndz Chain D Binding Site BS08

Receptor Information

>4ndz Chain D (length=654) Species: 9031,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYEYDIKDVGVDNAGAKAGLTFLVDLIKNKH
MNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQ
PSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVA
LKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASG
RQTVDAALAAAQTNAAADEEDDVVIIYNRVPKTASTSFTNIAYDLCAKNR
YHVLHINTTKNNPVMSLQDQVRFVKNVTSWKEMKPGFYHGHVSYLDFAKF
GVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDEC
VAAGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWALEQAKYNLINEYFLV
GVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKETI
AKLQQSEIWKMENEFYEFALEQFQFVRAHAVREKDGELYILAQNFFYEKI
YPKS

Ligand information

Ligand ID

NPO

InChI

InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H

InChIKey

BTJIUGUIPKRLHP-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	Oc1ccc(cc1)[N+]([O-])=O
ACDLabs 10.04	O=[N+]([O-])c1ccc(O)cc1
OpenEye OEToolkits 1.5.0	c1cc(ccc1[N+](=O)[O-])O

Formula

C6 H5 N O3

Name

P-NITROPHENOL

PDB chain

4ndz Chain B Residue 2011 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4ndz Deciphering the role of 2-O-sulfotransferase in regulating heparan sulfate biosynthesis
Resolution	3.45 Å
Binding residue (original residue number in PDB)	E1334 G1337 E1338
Binding residue (residue number reindexed from 1)	E633 G636 E637
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.8.2.-

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0008146	sulfotransferase activity
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4ndz, PDBe:4ndz, PDBj:4ndz
PDBsum	4ndz
PubMed
UniProt	P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q76KB1

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