Structure of PDB 8wak Chain o Binding Site BS06

Receptor Information
>8wak Chain o (length=1452) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEHGGCG
RYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFV
LGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVK
INNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRP
LKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIA
ANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKP
SDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLN
LSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVM
GIVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPL
WTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGEL
IMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGH
TIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQ
TFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVI
AVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTE
FFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQ
VVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQ
EDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLR
MIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQE
NATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGE
MVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPK
TPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTV
VAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKI
NAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFL
RCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWI
LETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHV
ISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEET
VDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGME
IP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8wak Chain o Residue 2489 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8wak Structural Visualization of de novo Transcription Initiation.
Resolution5.47 Å
Binding residue
(original residue number in PDB)		C114 C154 C184
Binding residue
(residue number reindexed from 1)		C104 C144 C149
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8wak, PDBe:8wak, PDBj:8wak
PDBsum8wak
PubMed38127763
UniProtA0A8D1DPV6

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