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BioLiP

Structure of PDB 6voy Chain A Binding Site BS06

Receptor Information
>6voy Chain A (length=276) Species: 11927,273057 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSPAELHSFTHCGQTALTLQGATTTEASNILRSCHACRKNNPQHQMPRGH
IRRGLLPNHIWQGDITHFKYKNTLYRLHVWVDTFSGAISATQKRKETSSE
AISSLLQAIAYLGKPSYINTDNGPAYISQDFLNMCTSLAIRHTTHVPYNP
TSSGLVQRSNGILKTLLYKYFTDKPDLPMDNALSIALWTINHLNVLTNCH
KTRWQLHHSPRLQPIPETRSLSNKQTHWYYFKLPGLNSRQWKGPQEALQE
AAGAALIPVSASSAQWIPWRLLKRAA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6voy Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6voy Structural basis of host protein hijacking in human T-cell leukemia virus integration.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		H6 H10 C33
Binding residue
(residue number reindexed from 1)		H7 H11 C34
Annotation score1
Enzymatic activity
Enzyme Commision number ?
2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004521 RNA endonuclease activity
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:6voy, PDBe:6voy, PDBj:6voy
PDBsum6voy
PubMed32561747
UniProtP14078;
P39476|DN7D_SACS2 DNA-binding protein 7d (Gene Name=sso7d)

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