Structure of PDB 7pg0 Chain B Binding Site BS05

Receptor Information
>7pg0 Chain B (length=822) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCH
SECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC
QDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLL
EGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEIS
GYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWS
KHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQ
ASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNV
TEFDGQDACGSNSWTVVDIDPPLRQNHPGWLMRGLKPWTQYAIFVKTLVT
FSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDP
NGNITHYLVFWERQAEDSELFELDYCYEDSAGECCSCPKTDSQILKELEE
SSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGYRIELQA
CNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEP
KEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTD
Ligand information
>7pg0 Chain I (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
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PDB7pg0 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
Resolution7.6 Å
Binding residue
(original residue number in PDB)		R488 D535 N547 H548 P549 G550 W551 R554
Binding residue
(residue number reindexed from 1)		R473 D520 N526 H527 P528 G529 W530 R533
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pg0, PDBe:7pg0, PDBj:7pg0
PDBsum7pg0
PubMed35074483
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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