Structure of PDB 6ryr Chain W Binding Site BS04

Receptor Information
>6ryr Chain W (length=708) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTC
PALKGKVQKILIWKWGPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFR
NYQRKNDMDEPPSEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRIL
NHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELM
TVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMG
LGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVV
TYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYEL
ITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTP
LQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHM
LRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGN
QVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLL
LQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNM
RQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDI
QAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRAAAA
AAAAAAAA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ryr Chain W Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ryr Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C452 H472 C475
Binding residue
(residue number reindexed from 1)		C7 H27 C30
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006338 chromatin remodeling

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ryr, PDBe:6ryr, PDBj:6ryr
PDBsum6ryr
PubMed32543371
UniProtQ14839|CHD4_HUMAN Chromodomain-helicase-DNA-binding protein 4 (Gene Name=CHD4)

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