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Structure of PDB 4oge Chain A Binding Site BS04

Receptor Information
>4oge Chain A (length=977) Species: 1115803 (Actinomyces naeslundii str. Howell 279) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHLRVGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDLSGIARRARRL
LHHRRTQLQQLDEVLRDLGFPIPSMAVRHIARHRGWRNPYSKVESLLSPA
EESPFMKRKICARQGVSPDVCKQLLRAVFKADSPRGSAVSRVAPDPLPGQ
GSFRRAPKCDPEFQRFRIISIVANLRISETKGENRPLTADERRHVVTFLT
EDSQADLTWVDVAEKLGVHRRDLRGTAVHTRSAARPPIDATDRIMRQTKI
SSLKTWWEEADSEQRGAMIRYLYEDPTDSECAEIIAELPEEDQAKLDSLH
LPAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEAINA
PVGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMADERD
KANRRRYNDNQEAMKKIQRDYGKEGYISRGDIVRLDALELQGCACLYCGT
TIGYHTCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSNTPFAVWAQKC
GIPHVGVKEAIGRVRGWRKQTSSEDLTRLKKEVIARLRRTQEDPEIDERS
MESVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSRINLIGE
KGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTGKEQTWK
QYTGSTVGAREHFEMWRGHMLHLTELFNERLAEDKVYVTQNIRLRLSDGN
AHTVNPSKLVSHRLGDGLTVQQIDRACTPALWCALTREKDFDEKNGLPAR
EDRAIRVHGHEIKSSDYIQVFSKRKKTDSDRDETPFGAIAVRGGFVEIGP
SIHHARIYRVEGKKPVYAMLRVFTHDLLSQRHGDLFSAVIPPQSISMRCA
EPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDFPNTTRW
RICGYDTNSKLTLKPIVLAAEGLENPSSAVNEIVELKGWRVAINVLTKVH
PTVVRRDALGRPRYSSRSNLPTSWTIE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4oge Chain A Residue 1204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4oge Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Resolution2.201 Å
Binding residue
(original residue number in PDB)		Q586 G588 G590
Binding residue
(residue number reindexed from 1)		Q465 G467 G469
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4oge, PDBe:4oge, PDBj:4oge
PDBsum4oge
PubMed24505130
UniProtJ3F2B0|CAS9_ACTNH CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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