Structure of PDB 1hfu Chain A Binding Site BS04

Receptor Information

>1hfu Chain A (length=500) Species: 5346 (Coprinopsis cinerea)

AIVNSVDTMTLTNANVSPDGFTRAGILVNGVHGPLIRGGKNDNFELNVVN
DLDNPTMLRPTSIHWHGLFQRGTNWADGADGVNQCPISPGHAFLYKFTPA
GHAGTFWYHSHFGTQYCDGLRGPMVIYDDNDPHAALYDEDDENTIITLAD
WYHIPAPSIQQPDATLINGKGRYVGGPAAELSIVNVEQGKKYRMRLISLS
CDPNWQFSIDGHELTIIEVDGELTEPHTVDRLQIFTGQRYSFVLDANQPV
DNYWIRAQPNKGRNGLAGTFANGVNSAILRYAGAANADPTTSANPNPAQL
NEADLHALIDPAAPGIPTPGAADVNLRFQLGFSGGRFTINGTAYESPSVP
TLLQIMSGAQSANDLLPAGSVYELPRNQVVELVVPAGVLGGPHPFHLHGH
AFSVVRSAGSSTYNFVNPVKRDVVSLGVTGDEVTIRFVTDNPGPWFFHCH
IEFHLMNGLAIVFAEDMANTVDANNPPVEWAQLCEIYDDLPPEATSIQTV

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 1hfu Chain A Residue 703

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1hfu Structure of the Laccase from Coprinus Cinereus at 1.68A Resolution: Evidence for Different Type 2 Cu-Depleted Isoforms
• Resolution: 1.68 Å
• Binding residue (original residue number in PDB): H66 H109 H453
• Binding residue (residue number reindexed from 1): H66 H109 H450
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H64 H66 H109 H111 H396 H399 H401 H451 C452 H453 I454 H457 L462
• Catalytic site (residue number reindexed from 1): H64 H66 H109 H111 H393 H396 H398 H448 C449 H450 I451 H454 L459
• Enzyme Commision number: 1.10.3.2: laccase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1hfu, PDBe:1hfu, PDBj:1hfu
• PDBsum: 1hfu
• PubMed: 11173497
• UniProt: Q9Y780