Structure of PDB 5ew2 Chain H Binding Site BS03

Receptor Information
>5ew2 Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ew2 Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.
Resolution3.59 Å
Binding residue
(original residue number in PDB)		I24 H71 R75 Y76 R77A N78 I79 Y117
Binding residue
(residue number reindexed from 1)		I9 H66 R70 Y71 R73 N74 I75 Y114
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ew2, PDBe:5ew2, PDBj:5ew2
PDBsum5ew2
PubMed27899589
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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