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BioLiP

Structure of PDB 7prv Chain A Binding Site BS03

Receptor Information
>7prv Chain A (length=321) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIID
KIRRKNCPACRYRKCLQAGMNLLTPTLVSLLEVIEPEVLYAGYDSSVPDS
TWRIMTTLNMLGGRQMIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMA
FALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSSELHR
LQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKRE
GNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAE
IITNQIPKYSNGNIKKLLFHQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7prv Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		V575 K579 L589 Q592 M593 L596 E755
Binding residue
(residue number reindexed from 1)		V120 K124 L134 Q137 M138 L141 E300
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7prv, PDBe:7prv, PDBj:7prv
PDBsum7prv
PubMed36747092
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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