Structure of PDB 6a94 Chain A Binding Site BS03

Receptor Information
>6a94 Chain A (length=370) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAI
ADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCA
ISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDD
SKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADL
EDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAGSGSGDILVGQID
DALKLANEGKVKEAQAAAEQLKTTINAYIQKYGQSISNEQKACKVLGIVF
FLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLV
YTLFNKTYRSAFSRYIQCQY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6a94 Chain A Residue 3004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6a94 Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H182 H183 E264 E318
Binding residue
(residue number reindexed from 1)		H114 H115 E196 E289
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6a94, PDBe:6a94, PDBj:6a94
PDBsum6a94
PubMed30723326
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P28223|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)

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