Structure of PDB 1dwe Chain H Binding Site BS02
Receptor Information
>1dwe Chain H (length=257) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
>1dwe Chain I (length=11) Species:
6421
(Hirudo medicinalis) [
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DFEEIPEEYLQ
Receptor-Ligand Complex Structure
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PDB
1dwe
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
F34 K36 R73 T74 R75 Y76 I82 F245
Binding residue
(residue number reindexed from 1)
F19 K21 R68 T69 R70 Y71 I78 F257
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1dwe
,
PDBe:1dwe
,
PDBj:1dwe
PDBsum
1dwe
PubMed
1939071
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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