Structure of PDB 1ad8 Chain H Binding Site BS02
Receptor Information
>1ad8 Chain H (length=250) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
>1ad8 Chain I (length=10) Species:
6421
(Hirudo medicinalis) [
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DFEEIPEEYL
Receptor-Ligand Complex Structure
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PDB
1ad8
Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
F34 Q38 L40 L65 R73 T74 R75A Y76 K81 I82
Binding residue
(residue number reindexed from 1)
F19 Q24 L26 L60 R68 T69 R70 Y71 K77 I78
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1ad8
,
PDBe:1ad8
,
PDBj:1ad8
PDBsum
1ad8
PubMed
9033393
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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