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BioLiP

Structure of PDB 7ssj Chain D Binding Site BS02

Receptor Information
>7ssj Chain D (length=218) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIIKLRKEIERLEEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLI
GLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSSMKGIRLKD
ELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHS
QAKTCRVDIQQLWKEVVITVSDDGTFKGEFSKGHGLLGMRERLEFANGSL
HIDTENGTKLTMAIPNNS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7ssj Chain D Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ssj An allosteric switch ensures efficient unidirectional information transmission by the histidine kinase DesK from Bacillus subtilis.
Resolution2.52 Å
Binding residue
(original residue number in PDB)		E289 N293
Binding residue
(residue number reindexed from 1)		E141 N145
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.13.3: histidine kinase.
Gene Ontology
Molecular Function
GO:0000155 phosphorelay sensor kinase activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000160 phosphorelay signal transduction system
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ssj, PDBe:7ssj, PDBj:7ssj
PDBsum7ssj
PubMed36693130
UniProtO34757|DESK_BACSU Sensor histidine kinase DesK (Gene Name=desK)

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