Structure of PDB 2vzy Chain D Binding Site BS02

Receptor Information

>2vzy Chain D (length=191) Species: 83332 (Mycobacterium tuberculosis H37Rv)

SRHWPLFDLRITTPRLQLQLPTEELCDQLIDTILEEDLPFNTLSHLWQQL
AGFKRDDWSLPLAVLVDGRAVGVQALSSKDFPITRQVDSGSWLGLRYQGH
GYGTEMRAAVLYFAFAELEAQVATSRSFVDNPASIAVSRRNGYRDNGLDR
VAREGAMAEALLFRLTRDDWQRHRTVEVRVDGFDRCRPLFG

Ligand information

• Ligand ID: FLC
• InChI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3
• InChIKey: KRKNYBCHXYNGOX-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
  OpenEye OEToolkits 1.5.0: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
  ACDLabs 10.04: O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]
• Formula: C6 H5 O7
• Name: CITRATE ANION
• PDB chain: 2vzy Chain D Residue 1214

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2vzy Rv0802C from Mycobacterium Tuberculosis: The First Structure of a Succinyltransferase with the Gnat Fold.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): R184 T186 D188
• Binding residue (residue number reindexed from 1): R164 T166 D168
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.8.1.-

Gene Ontology

Molecular Function

• GO:0008999 peptide-alanine-alpha-N-acetyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0061733 peptide-lysine-N-acetyltransferase activity
• GO:1990189 peptide-serine-alpha-N-acetyltransferase activity

Biological Process

• GO:0006104 succinyl-CoA metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2vzy, PDBe:2vzy, PDBj:2vzy
• PDBsum: 2vzy
• PubMed: 18997321
• UniProt: P9WQG7|Y802_MYCTU Acetyl- and succinyl-CoA transferase Rv0802c (Gene Name=Rv0802c)