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BioLiP

Structure of PDB 2gvq Chain C Binding Site BS02

Receptor Information
>2gvq Chain C (length=341) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNINEILKKLINKSDLEINEAEELAKAIIRGEVPEILVSAILVALRMKGE
SKNEIVGFARAMRELAIKIDVPNAIDTAGGLGTVNVSTASAILLSLVNPV
AKHGNRAVSGKSGSADVLEALGYNIIVPPERAKELVNKTNFVFLFAQYYH
PAMKNVANVRKTLGIRTIFNILGPLTNPANAKYQLMGVFSKDHLDLLSKS
AYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVTDFGIS
PIPIEKLIVNSAEDSAIKIVRAFLGKDEHVAEFIKINTAVALFALDRVGD
FREGYEYADHLIEKSLDKLNEIISMNGDVTKLKTIVVKSSG
Ligand information
Ligand IDBE2
InChIInChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)
InChIKeyRWZYAGGXGHYGMB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Nc1ccccc1C(O)=O
ACDLabs 10.04O=C(O)c1ccccc1N
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)O)N
FormulaC7 H7 N O2
Name2-AMINOBENZOIC ACID
ChEMBLCHEMBL14173
DrugBankDB04166
ZINCZINC000000047985
PDB chain2gvq Chain C Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2gvq Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
Resolution2.43 Å
Binding residue
(original residue number in PDB)		N109 H154 M157 R164
Binding residue
(residue number reindexed from 1)		N105 H150 M153 R160
Annotation score5
Enzymatic activity
Enzyme Commision number 2.4.2.18: anthranilate phosphoribosyltransferase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004048 anthranilate phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000162 tryptophan biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:2gvq, PDBe:2gvq, PDBj:2gvq
PDBsum2gvq
PubMed16714288
UniProtP50384|TRPD_SACS2 Anthranilate phosphoribosyltransferase (Gene Name=trpD)

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