Structure of PDB 1k7l Chain C Binding Site BS02

Receptor Information

>1k7l Chain C (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE
KTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD
LNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPF
CDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQ
EGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTE
SDAALHPLLQEIYRDMY

Ligand information

>1k7l Chain F (length=13) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ERHKILHRLLQEG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1k7l Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	D371 N415 H416 D418
Binding residue (residue number reindexed from 1)	D170 N214 H215 D217

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:1k7l, PDBe:1k7l, PDBj:1k7l
PDBsum	1k7l
PubMed	11698662
UniProt	Q07869\|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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