Structure of PDB 1d8h Chain C Binding Site BS02

Receptor Information
>1d8h Chain C (length=288) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMYRNVPIWAQKWKPTIKALQSINVKDLKIDPSFLNIIPDDDLTKSVQDW
VYATIYSIAPELRSFIELEMKFGVIIDAKGPDRVNPPVSSQCVFTELDAH
LTPNIDASLFKELSKYIRGISEVTENTGKFSIIESQTRDSVYRVGPRFLR
MSTDIKTGRVGQFIEKRHVAQLLLYSPKDSYDVKISLNLELPVPDNDPPE
KYKSQSPISERTKDRVSYIHNDSCTRIDITKVENHSETTHEVELEINTPA
LLNAFDNITNDSKEYASLIRTFLNNGTIIRRKLSSLSY
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1d8h Chain C Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1d8h Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R393 K456 R458
Binding residue
(residue number reindexed from 1)		R150 K213 R215
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E305 E307 R393 K409 K456 E496
Catalytic site (residue number reindexed from 1) E67 E69 R150 K166 K213 E245
Enzyme Commision number 3.6.1.74: mRNA 5'-phosphatase.
Gene Ontology
Molecular Function
GO:0004651 polynucleotide 5'-phosphatase activity

View graph for
Molecular Function
External links
PDB RCSB:1d8h, PDBe:1d8h, PDBj:1d8h
PDBsum1d8h
PubMed10589681
UniProtO13297|CET1_YEAST mRNA-capping enzyme subunit beta (Gene Name=CET1)

[Back to BioLiP]