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BioLiP

Structure of PDB 9eo8 Chain BBB Binding Site BS02

Receptor Information
>9eo8 Chain BBB (length=117) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KETAAAKFERQHMDSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAV
CSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHII
VACEGNPYVPVHFDASV
Ligand information
Ligand IDPT
InChIInChI=1S/Pt/q+2
InChIKeyHRGDZIGMBDGFTC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Pt++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Pt+2]
FormulaPt
NamePLATINUM (II) ION
ChEMBL
DrugBank
ZINC
PDB chain9eo8 Chain BBB Residue 209 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB9eo8 Picoplatin binding to proteins: X-ray structures and mass spectrometry data on the adducts with lysozyme and ribonuclease A.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		E49 D53 M79
Binding residue
(residue number reindexed from 1)		E42 D46 M72
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9eo8, PDBe:9eo8, PDBj:9eo8
PDBsum9eo8
PubMed38727007
UniProtP61824|RNAS1_BISBI Ribonuclease pancreatic (Gene Name=RNASE1)

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