Structure of PDB 8czk Chain B Binding Site BS02

Receptor Information

>8czk Chain B (length=400) Species: 9606 (Homo sapiens)

HMAQRAFPNPYADYNKSLAEGYFDAAGRLTPEFSQRLTNKIRELLQQMER
GLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCL
TKRSITFLCGDAGPLAVAAVLYHKMNNEKQAEDCITRLIHLNKIDPHAPN
EMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNF
TAKSPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVD
YVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEKYL
CDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRAC
KFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL

Ligand information

>8czk Chain D (length=6) Species: 32630 (synthetic construct)

GFLPEY

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8czk The mechanism of thia-Michael addition catalyzed by LanC enzymes.
• Resolution: 1.91 Å
• Binding residue (original residue number in PDB): Y62 Y210 E212 H219 P263 C264 D267 C276 H277
• Binding residue (residue number reindexed from 1): Y63 Y211 E213 H220 P264 C265 D268 C277 H278

Enzymatic activity

• Enzyme Commision number: 2.5.1.18: glutathione transferase.

Gene Ontology

Molecular Function

• GO:0004364 glutathione transferase activity
• GO:0004930 G protein-coupled receptor activity
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0016740 transferase activity
• GO:0017124 SH3 domain binding
• GO:0043295 glutathione binding
• GO:0046872 metal ion binding
• GO:0050750 low-density lipoprotein particle receptor binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0031179 peptide modification
• GO:1990748 cellular detoxification

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane

External links

• PDB: RCSB:8czk, PDBe:8czk, PDBj:8czk
• PDBsum: 8czk
• PubMed: 36634136
• UniProt: O43813|LANC1_HUMAN Glutathione S-transferase LANCL1 (Gene Name=LANCL1)