Structure of PDB 5ly2 Chain B Binding Site BS02
Receptor Information
>5ly2 Chain B (length=345) Species:
9606
(Homo sapiens) [
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PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASY
DDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTP
RYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDL
VEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWY
SVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDK
VTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCR
KDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
Ligand information
>5ly2 Chain F (length=8) Species:
32630
(synthetic construct) [
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YNTKSGWR
Receptor-Ligand Complex Structure
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PDB
5ly2
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Resolution
2.43 Å
Binding residue
(original residue number in PDB)
A69 N86 D135 G170 Y177 E190 H240 K241 T289 N290 C308 D311 M312
Binding residue
(residue number reindexed from 1)
A60 N77 D126 G161 Y168 E181 H231 K232 T280 N281 C299 D302 M303
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G161 Y168 H179 E181 H267 S279
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:5ly2
,
PDBe:5ly2
,
PDBj:5ly2
PDBsum
5ly2
PubMed
28382930
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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