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BioLiP

Structure of PDB 4cco Chain B Binding Site BS02

Receptor Information
>4cco Chain B (length=459) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLLCPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRAPTEELALTCSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
AGEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEE
PKCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGL
LLTKMPLAL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4cco Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4cco Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H340 D342 H405
Binding residue
(residue number reindexed from 1)		H159 D161 H224
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79: protein-L-histidine (3S)-3-hydroxylase.
External links
PDB RCSB:4cco, PDBe:4cco, PDBj:4cco
PDBsum4cco
PubMed24814345
UniProtQ9H6W3|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)

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