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BioLiP

Structure of PDB 1h8p Chain B Binding Site BS02

Receptor Information
>1h8p Chain B (length=88) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EECVFPFVYRNRKHFDCTVHGSLFPWCSLDADYVGRWKYCAQRDYAKCVF
PFIYGGKKYETCTKIGSMWMSWCSLSPNYDKDRAWKYC
Ligand information
Ligand IDPC
InChIInChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p+1
InChIKeyYHHSONZFOIEMCP-UHFFFAOYSA-O
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCC[N+](C)(C)C
CACTVS 3.341C[N+](C)(C)CCO[P](O)(O)=O
OpenEye OEToolkits 1.5.0C[N+](C)(C)CCOP(=O)(O)O
FormulaC5 H15 N O4 P
NamePHOSPHOCHOLINE
ChEMBLCHEMBL1235161
DrugBankDB03945
ZINCZINC000001532692
PDB chain1h8p Chain B Residue 1111 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1h8p Sperm Coating Mechanism from the 1.8 A Crystal Structure of Pdc-109-Phosphorylcholine Complex
Resolution1.82 Å
Binding residue
(original residue number in PDB)		Y75 G87 W93 Y100 W106
Binding residue
(residue number reindexed from 1)		Y54 G66 W72 Y79 W85
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008201 heparin binding
Biological Process
GO:0007338 single fertilization
GO:0033700 phospholipid efflux
GO:0048240 sperm capacitation
GO:1902492 positive regulation of sperm capacitation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1h8p, PDBe:1h8p, PDBj:1h8p
PDBsum1h8p
PubMed11937055
UniProtP02784|SFP1_BOVIN Seminal plasma protein PDC-109

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