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BioLiP

Structure of PDB 7zlj Chain A Binding Site BS02

Receptor Information
>7zlj Chain A (length=662) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YSQTWLASVVIIGLLVGYINYQHVYTLFENDKHFSHLADFEREMAYRTEM
GLYYSYYKTIINAPSFLEGVQEITHDTVTEHGHEINTLNRFNLYPEVILA
FLYRPFRAFAKSANWQIELCWQVNRGELRPVESCEGIGNPHYFYITGVFI
VAGTVASSIFYLGVLVSDSIFGGFLSVLCFAFNHGEATRVQWTPPLRESF
AFPFIIGHIAILTFVIKYKKSGHSMILLLTSMAVPALLFWQFTQFAFFTQ
ICSIFLAFSLDLIPFSTAKTVIHSHIISFLIGFLLLFGNEMMITALYFPS
ILALGMIIYISPLLSNLKFRPAYVLFLAIIFASITLGLKIGLSKGLGIED
DAHIFDILRSKFTSFANFHTRLYTCSAEFDFIQYSTIEKLCGTLLIPLAL
ISLVTFVFNFVKNTNLLWRNSEEIGENGEILYNVVQLCCSTVMAFLIMRL
KLFMTPHLCIVAALFANSKLLGGDRISKTIRVSALVGVIAILFYRGIPNI
RQQLNVKGEYSNPDQEMLFDWIQHNTKQDAVFAGTMPVMANVKLTTLRPI
VNHPHYEHVGIRERTLKVYSMFSKKPIAEVHKIMKEMGVNYFVFQLMNCS
NDERRPECVYRGMWDEEDPKNSGRTALCDLWILAANSKDNSRIAPFKIVY
NANRNYIVLKIL
Ligand information
Ligand IDIZU
InChIInChI=1S/C32H57O8P/c1-23(2)11-7-12-24(3)13-8-14-25(4)15-9-16-26(5)17-10-18-27(6)19-20-39-41(37,38)22-29-31(35)32(36)30(34)28(21-33)40-29/h11,13,15,17,27-36H,7-10,12,14,16,18-22H2,1-6H3,(H,37,38)/b24-13+,25-15-,26-17+/t27-,28+,29-,30+,31+,32-/m0/s1
InChIKeyMNRXJRFNBXECBJ-QWFISOLMSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CC(CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)CCOP(=O)(CC1C(C(C(C(O1)CO)O)O)O)O
OpenEye OEToolkits 2.0.7C[C@@H](CC/C=C(\C)/CC/C=C(/C)\CC/C=C(\C)/CCC=C(C)C)CCOP(=O)(C[C@H]1[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O
CACTVS 3.385C[C@H](CCO[P](O)(=O)C[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O)CC/C=C(C)/CC/C=C(/C)CC/C=C(C)/CCC=C(C)C
CACTVS 3.385C[CH](CCO[P](O)(=O)C[CH]1O[CH](CO)[CH](O)[CH](O)[CH]1O)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
FormulaC32 H57 O8 P
Name[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]methyl-[(3~{S},6~{E},10~{Z},14~{E})-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraenoxy]phosphinic acid
ChEMBL
DrugBank
ZINC
PDB chain7zlj Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zlj Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase.
Resolution3.63 Å
Binding residue
(original residue number in PDB)		E71 Y75 W262 F264 F267 C274 I376 L380 Y395 F401 M465 I469 R471 H577 E579
Binding residue
(residue number reindexed from 1)		E49 Y53 W240 F242 F245 C252 I354 L358 Y373 F379 M443 I447 R449 H555 E557
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0000030 mannosyltransferase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007399 nervous system development
GO:0018406 protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan
GO:0030154 cell differentiation
Cellular Component
GO:0005637 nuclear inner membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zlj, PDBe:7zlj, PDBj:7zlj
PDBsum7zlj
PubMed36604564
UniProtP34413|DPY19_CAEEL C-mannosyltransferase dpy-19 (Gene Name=dpy-19)

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