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BioLiP

Structure of PDB 7qen Chain A Binding Site BS02

Receptor Information
>7qen Chain A (length=465) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVEELIIDGFKSYATRTVITDWDPQFNAITGLNGSGKSNILDAICFVLG
IASMSTVRASSLQDLIYKRGQAGVTKASVTIVFDNTDKSNSPIGFTNSPQ
ISVTRQVVLGGTSKYLINGHRAPQQSVLQLFQSVQLNINNPNFLIMQGKI
TKVLNMKPSEILSLIEEAAGTKMFEDRREKAERTMSKKETKLQENRTLLT
EEIEPKLEKLRNEKRMFLEFQSTQTDLEKTERIVVSYEYYFDLVRNIVKQ
NEGIDLDTYRERSKQLNEKFQELRKKVNPNIMNMIENVEKKEAALKTMIK
TIEKDKMKIQETISKLNEYKRETLVKTWEKVTLDFGNIFADLLPNSFAKL
VPCEGKDVTQGLEVKVKLGNIWKESLIELSGGQRSLIALSLIMALLQFRP
APMYILDQVDAALDLSHTQNIGHLIKTRFKGSQFIVVSLKEGMFANANRV
FRTRFQDGTSVVSIM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qen A hold-and-feed mechanism drives directional DNA loop extrusion by condensin.
Resolution3.46 Å
Binding residue
(original residue number in PDB)		S61 L62 T112 Q124
Binding residue
(residue number reindexed from 1)		S61 L62 T112 Q124
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000217 DNA secondary structure binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0007059 chromosome segregation
GO:0007076 mitotic chromosome condensation
GO:0030261 chromosome condensation
GO:0051276 chromosome organization
GO:0051301 cell division
GO:0070058 tRNA gene clustering
GO:0070550 rDNA chromatin condensation
GO:1903342 negative regulation of meiotic DNA double-strand break formation
Cellular Component
GO:0000785 chromatin
GO:0000793 condensed chromosome
GO:0000796 condensin complex
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qen, PDBe:7qen, PDBj:7qen
PDBsum7qen
PubMed35653469
UniProtP38989|SMC2_YEAST Structural maintenance of chromosomes protein 2 (Gene Name=SMC2)

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