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Structure of PDB 6f5b Chain A Binding Site BS02

Receptor Information

>6f5b Chain A (length=114) Species: 9606 (Homo sapiens)

APVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDA
QRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDR
EKFEKVPGKYDMLQ

Ligand information

>6f5b Chain D (length=10)

gcctataggc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6f5b Structural basis for DNA break recognition by ARTD2/PARP2.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): N127 N128 N129 K130 G152 R153
• Binding residue (residue number reindexed from 1): N36 N37 N38 K39 G61 R62

Enzymatic activity

• Enzyme Commision number: 2.4.2.-
  2.4.2.30: NAD(+) ADP-ribosyltransferase.

External links

• PDB: RCSB:6f5b, PDBe:6f5b, PDBj:6f5b
• PDBsum: 6f5b
• PubMed: 30321391
• UniProt: Q9UGN5|PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (Gene Name=PARP2)

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