Structure of PDB 5w6v Chain A Binding Site BS02

Receptor Information
>5w6v Chain A (length=796) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNR
EVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGK
DRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRY
TPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAF
YKAQPVIEFMCEVLDIRNQPKPLTDSQRVRFTKEIKGLKVEVTHCKRKYR
VCNVTRRPASHQTFPECTVAQYFKQKYNLQLKYPHLPCLQVQKHTYLPLE
VCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDP
YIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQF
YNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFC
KYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM
ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVI
FLGADVTHPPAKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYM
VRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLE
KDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFE
FDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTR
SVSIPAPAYYARLVAFRARYHLVDDPQALAKAVQVHQDTLRTMYFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5w6v Multivalent Recruitment of Human Argonaute by GW182.
Resolution2.828 Å
Binding residue
(original residue number in PDB)		Y441 N442 F585 Q587 P588 D617 A618 L648 I649 Y652 F657 K658 E693
Binding residue
(residue number reindexed from 1)		Y401 N402 F545 Q547 P548 D574 A575 L605 I606 Y609 F614 K615 E650
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0035198 miRNA binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006417 regulation of translation
GO:0010501 RNA secondary structure unwinding
GO:0016525 negative regulation of angiogenesis
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196 miRNA processing
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
GO:0043488 regulation of mRNA stability
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070922 RISC complex assembly
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043232 intracellular non-membrane-bounded organelle
GO:0070578 RISC-loading complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5w6v, PDBe:5w6v, PDBj:5w6v
PDBsum5w6v
PubMed28781232
UniProtQ9UL18|AGO1_HUMAN Protein argonaute-1 (Gene Name=AGO1)

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