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BioLiP

Structure of PDB 4nca Chain A Binding Site BS02

Receptor Information
>4nca Chain A (length=683) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPRK
PIPHLTGLLVPVLTLEDLHEEEGSLALSLPWEERRRRTREIASWIGRRLG
LGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLD
GAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEG
VQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALL
GLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLL
WTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQD
EFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFL
LLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRL
PAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4nca Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Resolution2.489 Å
Binding residue
(original residue number in PDB)		L267 E268 H271 K329 W415 H445 G480 G481 D590 V606 R608 F610 F647 F649 K664 R668
Binding residue
(residue number reindexed from 1)		L265 E266 H269 K327 W413 H443 G478 G479 D588 V604 R606 F608 F645 F647 K662 R666
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:4nca, PDBe:4nca, PDBj:4nca
PDBsum4nca
PubMed24374628
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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