BioLiP

Structure of PDB 2xni Chain A Binding Site BS02

Receptor Information

>2xni Chain A (length=181) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCIN
GVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTC
GSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGH
AVGLFRAAVCTRGVAKAVDFIPVENLETTMR

Ligand information

>2xni Chain D (length=16) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GSVVIVGRIVLSGKPA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2xni Novel Macrocyclic Hcv Ns3 Protease Inhibitors Derived from Alpha-Amino Cyclic Boronates.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	T4 Y6 A7
Binding residue (residue number reindexed from 1)	T5 Y7 A8

Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H58 D82 G138 S140
Enzyme Commision number	2.7.7.48: RNA-directed RNA polymerase. 3.4.21.98: hepacivirin. 3.4.22.- 3.6.1.15: nucleoside-triphosphate phosphatase. 3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0019087	transformation of host cell by virus

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Molecular Function

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Biological Process

PDB	RCSB:2xni, PDBe:2xni, PDBj:2xni
PDBsum	2xni
PubMed	20801653
UniProt	P27958\|POLG_HCV77 Genome polyprotein