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BioLiP

Structure of PDB 1vfc Chain A Binding Site BS02

Receptor Information
>1vfc Chain A (length=63) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMI
KDRWRTMKRLGMN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1vfc Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities
ResolutionN/A
Binding residue
(original residue number in PDB)		K447 Q448 K449 W450 M486 D489 R490
Binding residue
(residue number reindexed from 1)		K10 Q11 K12 W13 M49 D52 R53
Binding affinityPDBbind-CN: Kd=0.75uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0031848 protection from non-homologous end joining at telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1vfc, PDBe:1vfc, PDBj:1vfc
PDBsum1vfc
PubMed15608118
UniProtQ15554|TERF2_HUMAN Telomeric repeat-binding factor 2 (Gene Name=TERF2)

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