BioLiP

Structure of PDB 1lvm Chain A Binding Site BS02

Receptor Information

>1lvm Chain A (length=229) Species: 12227 (Tobacco etch virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GHHHHHHHGESLFKGPRDYNPISSTICHLTNESDGHTTSLYGIGFGPFII
TNKHLFRRNNGTLLVQSLHGVFKVKNTTTLQQHLIDGRDMIIIRMPKDFP
PFPQKLKFREPQREERICLVTTNFQTKSMSSMVSDTSCTFPSSDGIFWKH
WIQTKDGQCGSPLVSTRDGFIVGIHSASNFTNTNNYFTSVPKNFMELLTN
QEAQQWVSGWRLNADSVLWGGHKVFMDKP

Ligand information

>1lvm Chain E (length=7) Species: 12227 (Tobacco etch virus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EATQLMN

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1lvm Structural basis for the substrate specificity of tobacco etch virus protease.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	V63 F64 K65 K67 D90
Binding residue (residue number reindexed from 1)	V71 F72 K73 K75 D98

Enzymatic activity

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.
3.4.-.-
3.4.22.44: nuclear-inclusion-a endopeptidase.
3.4.22.45: helper-component proteinase.
3.6.4.-

Gene Ontology

	Molecular Function
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Biological Process

PDB	RCSB:1lvm, PDBe:1lvm, PDBj:1lvm
PDBsum	1lvm
PubMed	12377789
UniProt	P04517\|POLG_TEV Genome polyprotein