Structure of PDB 1ebp Chain A Binding Site BS02

Receptor Information

>1ebp Chain A (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQL
EDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRY
HRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVD
VSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFW
SAWSEPVSLLT

Ligand information

>1ebp Chain D (length=16) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

TYSCHFGPLTWVCKPQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1ebp Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	S91 S92 F93 V94
Binding residue (residue number reindexed from 1)	S82 S83 F84 V85

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004896	cytokine receptor activity

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1ebp, PDBe:1ebp, PDBj:1ebp
PDBsum	1ebp
PubMed	8662530
UniProt	P19235\|EPOR_HUMAN Erythropoietin receptor (Gene Name=EPOR)

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