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BioLiP

Structure of PDB 1bci Chain A Binding Site BS02

Receptor Information
>1bci Chain A (length=123) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNN
DINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVG
EKKEVPFIFNQVTEMVLEMSLEV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1bci Chain A Residue 140 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1bci Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2.
ResolutionN/A
Binding residue
(original residue number in PDB)		D43 D93 A94 N95
Binding residue
(residue number reindexed from 1)		D28 D78 A79 N80
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.1.4: phospholipase A2.
3.1.1.5: lysophospholipase.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0008289 lipid binding

View graph for
Molecular Function
External links
PDB RCSB:1bci, PDBe:1bci, PDBj:1bci
PDBsum1bci
PubMed9665851
UniProtP47712|PA24A_HUMAN Cytosolic phospholipase A2 (Gene Name=PLA2G4A)

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