Structure of PDB 1ah0 Chain A Binding Site BS02
Receptor Information
>1ah0 Chain A (length=315) Species:
9823
(Sus scrofa) [
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ASHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQN
ENEVGLGLQEKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLK
LDYLDLYLIHWPTGFKPGKDPFPLDGDGNVVPDESDFVETWEAMEELVDE
GLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLTQEKLIEYCK
SKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIR
FPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCAL
MSCASHKDYPFHEEY
Ligand information
Ligand ID
SBI
InChI
InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
InChIKey
LXANPKRCLVQAOG-NSHDSACASA-N
SMILES
Software
SMILES
CACTVS 3.341
Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
CACTVS 3.341
Fc1ccc2OCC[C]3(NC(=O)NC3=O)c2c1
OpenEye OEToolkits 1.5.0
c1cc2c(cc1F)C3(CCO2)C(=O)NC(=O)N3
OpenEye OEToolkits 1.5.0
c1cc2c(cc1F)[C@@]3(CCO2)C(=O)NC(=O)N3
ACDLabs 10.04
Fc3ccc2OCCC1(C(=O)NC(=O)N1)c2c3
Formula
C11 H9 F N2 O3
Name
SORBINIL
ChEMBL
CHEMBL266497
DrugBank
DB02712
ZINC
ZINC000000002070
PDB chain
1ah0 Chain A Residue 320 [
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Receptor-Ligand Complex Structure
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PDB
1ah0
A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
W20 Y48 H110 W111 F122
Binding residue
(residue number reindexed from 1)
W20 Y48 H110 W111 F122
Annotation score
1
Binding affinity
BindingDB: IC50=1100nM
Enzymatic activity
Catalytic site (original residue number in PDB)
D43 Y48 K77 H110
Catalytic site (residue number reindexed from 1)
D43 Y48 K77 H110
Enzyme Commision number
1.1.1.21
: aldose reductase.
1.1.1.300
: NADP-retinol dehydrogenase.
1.1.1.372
: D/L-glyceraldehyde reductase.
1.1.1.54
: allyl-alcohol dehydrogenase.
Gene Ontology
Molecular Function
GO:0001758
retinal dehydrogenase activity
GO:0004032
aldose reductase (NADPH) activity
GO:0016491
oxidoreductase activity
GO:0036130
prostaglandin H2 endoperoxidase reductase activity
GO:0047655
allyl-alcohol dehydrogenase activity
GO:0047956
glycerol dehydrogenase (NADP+) activity
GO:0052650
all-trans-retinol dehydrogenase (NADP+) activity
Biological Process
GO:0001523
retinoid metabolic process
GO:0006629
lipid metabolic process
GO:0006693
prostaglandin metabolic process
GO:0042572
retinol metabolic process
Cellular Component
GO:0005737
cytoplasm
GO:0005829
cytosol
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Molecular Function
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External links
PDB
RCSB:1ah0
,
PDBe:1ah0
,
PDBj:1ah0
PDBsum
1ah0
PubMed
9195881
UniProt
P80276
|ALDR_PIG Aldo-keto reductase family 1 member B1 (Gene Name=AKR1B1)
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