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BioLiP

Structure of PDB 3ox7 Chain U Binding Site BS01

Receptor Information
>3ox7 Chain U (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSALAHHNDIALLK
IRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLYPE
QLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPL
VCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ox7 The binding mechanism of a peptidic cyclic serine protease inhibitor
Resolution1.58 Å
Binding residue
(original residue number in PDB)		H57 C58 D60A Y60B H99 D189 S190 C191 Q192 G193 S195 S214 W215 G219 E244
Binding residue
(residue number reindexed from 1)		H46 C47 D50 Y51 H92 D190 S191 C192 Q193 G194 S196 S215 W216 G219 E245
Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ox7, PDBe:3ox7, PDBj:3ox7
PDBsum3ox7
PubMed21802428
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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