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BioLiP

Structure of PDB 7f8v Chain R Binding Site BS01

Receptor Information
>7f8v Chain R (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLA
VACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYS
AICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQ
CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLLAKKR
VVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSY
ASACVNPLVYCFMHRRFRQACLETC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7f8v Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R57 P114 N115 L116 M134 V138 Y189 V198 Q204 V206 H207 L222 V349 N353 R356 H364 R365 S368 I372 H376 Y380
Binding residue
(residue number reindexed from 1)		R3 P60 N61 L62 M80 V84 Y135 V144 Q150 V152 H153 L168 V219 N223 R226 H234 R235 S238 I242 H246 Y250
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004951 cholecystokinin receptor activity
GO:0005515 protein binding
GO:0015054 gastrin receptor activity
GO:0017046 peptide hormone binding
GO:0031741 type B gastrin/cholecystokinin receptor binding
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
Biological Process
GO:0001696 gastric acid secretion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0038188 cholecystokinin signaling pathway
GO:0045851 pH reduction
GO:0048565 digestive tract development
GO:0048732 gland development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Biological Process
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Cellular Component
External links
PDB RCSB:7f8v, PDBe:7f8v, PDBj:7f8v
PDBsum7f8v
PubMed34556863
UniProtP32239|GASR_HUMAN Gastrin/cholecystokinin type B receptor (Gene Name=CCKBR)

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